They work by mimicking the natural hormone GLP-1, which plays a role in regulating appetite and digestion
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At least in rats, they've shown, or was it mice, I think it might have been rats, but multiple studies showing that it's released from the cold in the brain
Appetite dysregulation
[4] [5] GLP-1 receptor agonists mimic this endogenous hormone by binding to GLP-1 receptors located throughout the body, including the pancreas, brain, gastrointestinal tract, and cardiovascular system